Table 1.
KPNC: Characteristics of women diagnosed with hormone receptor-positive breast cancer from January 1996–June 2007 (N=13,753)
| non-Hispanic White |
Hispanic | African American |
Chinese | Japanese | Filipino | South Asian | p-value | No initiation° of adjuvant hormonal tx |
Initiation° of adjuvant hormonal tx |
p-value | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n (%)* | n (%)* | n (%)* | n (%)* | n (%)* | n (%)* | n (%)* | n (%)* | n (%)* | ||||
| 10,443 (75.9) | 1,089 (8.0) | 841 (6.1) | 497 (3.6) | 206 (1.5) | 579 (4.2) | 98 (0.7) | 4,185 (30.4) | 9,568 (69.6) | ||||
| Background characteristics | ||||||||||||
| Age at diagnosis (mean±SD) | 60.4 ± 10.9 | 56.0 ± 11.5 | 56.7 ± 11.8 | 56.0 ± 11.0 | 59.3 ± 10.8 | 54.6 ± 10.9 | 51.9 ± 11.2 | <0.001 | 58.0 ± 12.0 | 59.9 ± 10.8 | <0.001 | |
| Year of diagnosis (dx) | ||||||||||||
| 1996 | 793 (7.6) | 63 (5.8) | 43 (5.1) | 32 (6.4) | 15 (7.3) | 34 (5.9) | 5 (5.1) | 0.001 | 542 (13.0) | 443 (4.6) | <0.001 | |
| 1997 | 791 (7.6) | 57 (5.2) | 87 (9.8) | 35 (7.0) | 19 (9.2) | 28 (4.8) | 5 (5.1) | 373 (8.9) | 644 (6.7) | |||
| 1998 | 854 (8.2) | 87 (8.0) | 59 (7.0) | 28 (5.6) | 14 (6.8) | 30 (5.2) | 10 (10.2) | 346 (8.3) | 736 (7.7) | |||
| 1999 | 880 (8.4) | 89 (8.2) | 83 (9.9) | 28 (5.6) | 21 (10.2) | 47 (8.1) | 13 (13.3) | 330 (7.9) | 831 (8.7) | |||
| 2000 | 895 (8.6) | 89 (8.2) | 70 (8.3) | 32 (6.4) | 23 (11.2) | 51 (8.8) | 6 (6.1) | 289 (6.9) | 877 (9.2) | |||
| 2001 | 975 (9.3) | 99 (9.1) | 69 (8.2) | 43 (8.7) | 23 (11.2) | 49 (8.5) | 5 (5.1) | 327 (7.8) | 936 (9.8) | |||
| 2002 | 1,014 (9.7) | 108 (9.9) | 80 (9.5) | 63 (12.7) | 13 (6.3) | 57 (9.8) | 7 (7.1) | 349 (8.3) | 993 (10.4) | |||
| 2003 | 871 (8.3) | 95 (8.7) | 69 (8.2) | 47 (9.5) | 12 (5.8) | 53 (9.2) | 10 (10.2) | 341 (8.2) | 816 (8.5) | |||
| 2004 | 889 (8.5) | 108 (9.9) | 76 (9.0) | 54 (10.9) | 20 (9.7) | 60 (10.4) | 11 (11.2) | 326 (7.8) | 892 (9.3) | |||
| 2005 | 971 (9.3) | 126 (11.6) | 78 (9.3) | 47 (9.5) | 20 (9.7) | 59 (10.2) | 8 (8.2) | 389 (9.3) | 920 (9.6) | |||
| 2006 | 1,005 (9.6) | 121 (11.1) | 85 (10.1) | 53 (10.7) | 17 (8.3) | 77 (13.3) | 11 (11.2) | 375 (9.0) | 994 (10.4) | |||
| 2007 | 505 (4.8) | 47 (4.3) | 47 (5.6) | 35 (7.0) | 9 (4.4) | 34 (5.9) | 7 (7.1) | 198 (4.7) | 486 (5.1) | |||
| Marital status1 | ||||||||||||
| Single, widowed, divorced | 3,783 (37.3) | 341 (32.3) | 406 (50.6) | 123 (25.4) | 65 (32.5) | 161 (28.1) | 26 (27.1) | <0.001 | 1,588 (39.4) | 3,317 (35.6) | <0.001 | |
| Married or living with partner | 6,354 (62.7) | 696 (67.7) | 396 (49.4) | 358 (74.6) | 135 (67.5) | 413 (71.9) | 70 (72.9) | 2,443 (60.6) | 6,001 (64.4) | |||
| Socioeconomic status2** | ||||||||||||
| Lowest quintile | 270 (2.9) | 80 (8.0) | 111 (14.3) | 10 (2.1) | 2 (1.0) | 21 (3.9) | 2 (2.3) | <0.001 | 139 (3.7) | 357 (4.1) | 0.481 | |
| 2nd quintile | 909 (9.6) | 171 (17.1) | 212 (27.3) | 29 (6.2) | 7 (3.7) | 55 (10.2) | 5 (5.8) | 443 (11.7) | 945 (10.8) | |||
| 3rd quintile | 1,789 (18.9) | 212 (21.1) | 176 (22.7) | 54 (11.6) | 27 (14.1) | 128 (23.8) | 13 (14.9) | 718 (19.0) | 1,681 (19.2) | |||
| 4th quintile | 2,778 (29.3) | 304 (30.3) | 165 (21.2) | 152 (32.6) | 55 (28.6) | 186 (34.6) | 24 (27.6) | 1,093 (28.8) | 2,571 (29.4) | |||
| Highest quintile | 3,718 (39.3) | 236 (23.5) | 113 (14.5) | 222 (47.5) | 101 (52.6) | 148 (27.5) | 43 (49.4) | 1,394 (36.8) | 3,187 (36.5) | |||
| Health-related indicators & tumor characteristics | ||||||||||||
| Charlson comorbidity index | ||||||||||||
| 0 | 8,707 (83.4) | 886 (81.3) | 639 (76.0) | 423 (85.1) | 166 (80.6) | 472 (81.5) | 85 (86.7) | <0.001 | 3,444 (82.3) | 7,934 (82.9) | 0.577 | |
| 1 | 1,293 (12.4) | 163 (15.0) | 137 (16.3) | 64 (12.9) | 25 (12.1) | 74 (12.8) | 9 (9.2) | 556 (13.3) | 1,209 (12.6) | |||
| ≥2 | 443 (4.2) | 40 (3.7) | 65 (7.7) | 10 (2.0) | 15 (7.3) | 33 (5.7) | 4 (4.1) | 185 (4.4) | 425 (4.4) | |||
| SEER summary stage | ||||||||||||
| Localized | 7,245 (69.4) | 699 (64.2) | 538 (64.0) | 358 (72.0) | 148 (71.8) | 384 (66.3) | 63 (64.3) | 0.001 | 2,915 (69.6) | 6,520 (68.1) | 0.032 | |
| Regional, direct extension or LN | 2,999 (28.7) | 367 (33.7) | 287 (34.1) | 131 (26.4) | 54 (26.2) | 178 (30.7) | 31 (31.6) | 1,176 (28.1) | 2,871 (30.0) | |||
| Regional, direct extension + LN | 199 (1.9) | 23 (2.1) | 16 (1.9) | 8 (1.6) | 4 (2.0) | 17 (3.0) | 4 (4.1) | 94 (2.3) | 177 (1.9) | |||
| Tumor size | ||||||||||||
| <1 cm | 1,934 (19.8) | 178 (17.7) | 136 (17.5) | 97 (21.1) | 39 (20.1) | 97 (18.5) | 13 (14.0) | 0.285 | 1,050 (27.2) | 1,444 (16.1) | <0.001 | |
| ≥1 cm | 7,857 (80.2) | 829 (82.3) | 641 (82.5) | 363 (78.9) | 155 (79.9) | 428 (81.5) | 80 (86.0) | 2,818 (72.8) | 7,535 (83.9) | |||
| Histologic type3 | ||||||||||||
| Ductal | 7,217 (69.5) | 764 (70.7) | 588 (70.6) | 370 (74.8) | 152 (73.8) | 442 (76.9) | 67 (69.0) | <0.001 | 2,960 (71.3) | 6,640 (69.8) | <0.001 | |
| Lobular/ mixed lobular | 2,299 (22.1) | 207 (19.2) | 162 (19.4) | 70 (14.1) | 37 (18.0) | 80 (13.9) | 15 (15.5) | 743 (17.9) | 2,127 (22.3) | |||
| Other specified histology | 866 (8.4) | 109 (10.1) | 83 (10.0) | 55 (11.1) | 17 (8.2) | 53 (9.2) | 15 (15.5) | 449 (10.8) | 749 (7.9) | |||
| Tumor gradea | ||||||||||||
| Grade I | 2,795 (30.4) | 250 (25.7) | 151 (19.9) | 115 (25.8) | 60 (32.8) | 105 (19.8) | 21 (23.3) | <0.001 | 1,089 (29.8) | 2,408 (28.3) | <0.001 | |
| Grade II | 4,517 (49.1) | 488 (50.3) | 378 (49.8) | 222 (49.9) | 83 (45.3) | 276 (52.1) | 43 (47.8) | 1,691 (46.3) | 4,316 (50.6) | |||
| Grade III/IV | 1,886 (20.5) | 233 (24.0) | 230 (30.3) | 108 (24.3) | 40 (21.9) | 149 (28.1) | 26 (28.9) | 872 (23.9) | 1,800 (21.1) | |||
| Treatment for breast cancer | ||||||||||||
| Surgery and radiation3 | ||||||||||||
| Mastectomy ± radiation | 4,175 (40.4) | 458 (42.9) | 311 (37.1) | 224 (45.5) | 86 (42.6) | 310 (53.8) | 48 (49.5) | <0.001 | 1,581 (38.1) | 4,031 (42.6) | <0.001 | |
| Lumpectomy + radiation | 4,343 (42.0) | 383 (35.9) | 330 (39.3) | 185 (37.6) | 80 (39.6) | 166 (28.8) | 32 (33.0) | 1,547 (37.3) | 3,972 (42.0) | |||
| Lumpectomy, no radiation | 1,630 (15.8) | 203 (19.0) | 169 (20.1) | 74 (15.0) | 32 (15.8) | 92 (16.0) | 16 (16.5) | 912 (22.0) | 1,304 (13.8) | |||
| No surgery | 186 (1.8) | 23 (2.2) | 29 (3.5) | 9 (1.8) | 4 (2.0) | 8 (1.4) | 1 (1.0) | 106 (2.6) | 154 (1.6) | |||
| Chemotherapy3 | 3,948 (38.0) | 532 (49.2) | 361 (43.4) | 213 (43.0) | 86 (41.8) | 283 (49.0) | 49 (50.5) | <0.001 | 1,723 (41.5) | 3,749 (39.4) | 0.021 | |
°
Initiation=2 or more prescriptions filled within the first year after diagnosis
*
Percents based on non-missing values;
**
Quintiles determined from Census block-group level SES distribution of the state of California
1
2.9% missing;
2
8.9% missing;
3
≤1% missing;
a
11.5% missing