Table 2.
KPNC: Logistic Regression: Initiationa of adjuvant hormonal therapy among women diagnosed with hormone receptor-positive breast cancer (N=10,548)
| Initiationa | |||
|---|---|---|---|
| N (%) | aOR (95% CI) | ||
| Main exposure | |||
| Race/ethnicity | |||
| Non-Hispanic White | 5,633 (71.0) | Ref | |
| Hispanic | 553 (66.0) | 0.82 (0.71, 0.96)1 | |
| African American | 449 (68.7) | 1.03 (0.85, 1.23) | |
| Chinese | 264 (65.7) | 0.78 (0.63, 0.98)1 | |
| Japanese | 121 (74.7) | 1.27 (0.89, 1.82) | |
| Filipino | 346 (72.4) | 1.10 (0.89, 1.36) | |
| South Asian | 50 (66.7) | 0.91 (0.55, 1.52) | |
| Covariates | |||
| Age at diagnosis (continuous years) | n/a | 1.02 (1.01, 1.02)3 | |
| Year of diagnosis (continuous) | n/a | 1.08 (1.06, 1.09)3 | |
| Relationship status | |||
| Single, widowed, divorced | 2,601 (67.8) | Ref | |
| Married or living with partner | 4,815 (71.7) | 1.28 (1.17, 1.39)3 | |
| Socioeconomic status* | |||
| Lowest quintile | 308 (71.6) | Ref | |
| 2nd quintile | 806 (68.5) | 0.86 (0.67, 1.10) | |
| 3rd quintile | 1,441 (70.4) | 0.90 (0.71, 1.14) | |
| 4th quintile | 2,200 (70.8) | 0.92 (0.73, 1.15) | |
| Highest quintile | 2,661 (70.3) | 0.89 (0.71, 1.12) | |
| Charlson comorbidity index | |||
| 0 | 6,174 (70.8) | Ref | |
| 1 | 898 (67.8) | 0.78 (0.69, 0.89)3 | |
| ≥2 | 344 (69.2) | 0.76 (0.62, 0.93)2 | |
| SEER sumary stage | |||
| Localized | 5,026 (70.0) | Ref | |
| Regional (direct extension or LN) | 2,254 (71.3) | 1.12 (1.01, 1.25)1 | |
| Regional (direct extension + LN) | 136 (67.3) | 0.93 (0.68, 1.28) | |
| Histologic type | |||
| Ductal | 5,640 (69.8) | Ref | |
| Lobular/ mixed lobular | 1,293 (75.0) | 1.15 (1.02, 1.30)1 | |
| Other specified histology | 483 (64.8) | 0.75 (0.64, 0.88)2 | |
| Tumor grade | |||
| Grade I | 2,107 (69.2) | Ref | |
| Grade II | 3,762 (72.0) | 1.16 (1.04, 1.28)2 | |
| Grade III/IV | 1,547 (67.9) | 1.04 (0.92, 1.18) | |
| Primary breast cancer treatment | |||
| Mastectomy with/without radiation | 3,097 (72.5) | Ref | |
| Lumpectomy with radiation | 3,193 (72.6) | 1.01 (0.91, 1.11) | |
| Lumpectomy, no radiation | 1,033 (59.5) | 0.52 (0.46, 0.59)3 | |
| No surgery | 93 (65.5) | 0.65 (0.45, 0.93)1 | |
| Chemotherapy treatment | |||
| No use of chemotherapy | 4,434 (71.3) | Ref | |
| Use of chemotherapy | 2,982 (68.9) | 1.01 (0.90, 1.13) | |
a
Initiation=2 or more filled prescriptions for adjuvant hormonal therapy in first year after diagnosis
1
p<0.05;
2
p<0.01;
3
p<0.001