FIGURE 1.

Crystal structure of GS-A bound to IN CCD dimer. A, view of the IN CCD dimer complexed with two molecules of GS-A colored in orange. Each individual CCD monomer is colored in either green or tan. The active site residues are highlighted in red. B, view of GS-A (orange) and GS-B (gray) in the binding pocket at the CCD dimer interface. Key residues in the binding pockets are identified. Resistance mutations at positions 201 and 222 are not near the tBPQA binding site. Val-201 is at the CCD dimer interface but near the C-terminal end of CCD, and Asn-222 is in the C-terminal domain.