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. 2012 Apr 25;287(25):21244–21252. doi: 10.1074/jbc.M111.337741

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© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 3. — Interactions between loops A, B, and C at the β+/α− interface. A, averaged normalized glycine dose-response curves for the αChLa (○), αChLb (▾), and αChLaLb (●) GlyRs. B, averaged normalized glycine dose-response curves for the αChLa (○), αChLc (Δ), and αChLaLc (●) GlyRs. C, averaged normalized glycine dose-response curves for the αChLb (▾) and αChLc (Δ) and αChLbLc (●) GlyRs. D, Interaction energy between loops A and B (La–Lb), loops A and C (La–Lc), and loops B and C (Lb–Lc) (*, p < 0.05 and **, p < 0.01 using Student's t test). The interaction energy is calculated, for instance between loops A and B, using the formula ΔΔG (interaction) = ΔΔG (αChLaLb GlyR) − ΔΔG (αChLa GlyR) − ΔΔG (αChLb GlyR).