TABLE 1.
rs11200638 SNP Genotyping of European patients with and without IVD degeneration
| Genotype | Degeneration grade |
n | Relative HTRA1 expressiona | p valueb | |||
|---|---|---|---|---|---|---|---|
| 1 (n = 8) | 2 (n = 7) | 3 (n = 10) | 4 (n = 10) | ||||
| GG | 5 | 5 | 7 | 7 | 23 | 204.1 ± 35.6 | |
| GA | 2 | 2 | 3 | 3 | 8 | 307 ± 87.3 | 0.20 |
| AA | 1 | 0 | 0 | 0 | 1 | 14.9 | |
| GA + AA | 3 | 2 | 3 | 3 | 9 | 274.5 ± 83.5 | 0.37 |
| G allele | 12 | 12 | 17 | 17 | |||
| A allelec | 4 (25%) | 2 (14.3%) | 3 (15%) | 3 (15%) | |||
| p = 0.4d | p = 0.37d | p = 0.37d | |||||
a Comparisons were made between HTRA1 expression levels ± S.E. in IVD tissue and genotype frequency in patients where both RNA and DNA samples were available (n = 32).
b Student's t test was used to compare HTRA1 expression levels between patients carrying the risk allele (GA/AA) and those homozygous for the wild type allele (GG).
c Percentages refer to risk allele (A) frequency.
d The χ2 test was used to evaluate the significance of differences in risk allele (A) frequency between patients with IVD degeneration (grades 2–4) and control patients without IVD degeneration (grade 1) (n = 35).