TABLE 2.

Electrophysiological characteristics of the K_v1.5+K_vβ1.3 current following exposure to different PKC inhibitors

Data represent the mean ± S.E. τ_fast: fast inactivation kinetics; τ_slow: slow inactivation kinetics; τ_deac: deactivation kinetics; V_h: half-voltage of activation. Statistically significant differences are indicated by asterisks.

	Concentration	Inactivation	τfast	τslow	τdeac	Vh
	μm	%	ms	ms	ms	mV
Control	0	70 ± 2	3.5 ± 0.3	120 ± 8.2	47 ± 0.4	−21 ± 0.7
Calphostin C	0.2, 3	32 ± 6*	103 ± 32a		108 ± 24*	−8 ± 3*
Gö6976	0.2	57 ± 0.2*	10 ± 0.7*	124 ± 8.5	51 ± 6	−20 ± 3.4
Gö6983	5	60 ± 3*	6 ± 0.9*	152 ± 22	63 ± 3*	−17 ± 0.7*
Hispidin	5	59 ± 2*	5 ± 0.5*	104 ± 9*	58 ± 0.4*	−19 ± 0.6

^a The inactivation process of K_v1.5+K_vβ1.3 channels after treatment with calphostin C could only be fitted to a monoexponential equation.