Table 10.

Asymmetrical effects of cumulative life stress on the brain

	Original region (MNI coordinates)	Mean ± SD of original cluster	Mean ± SD of inverted cluster	Test of the difference between regions
Right putamen	+28, +7, +0	−0.136 ± 0.132	−0.092 ± 0.122	F = 3.675, p = 0.056
Left putamen	−21, +11, +10	−0.161 ± 0.123	−0.149 ± 0.127	F = 0.259, p = 0.612
Right occipital lobe	+30, −88, −13	0.076 ± 0.253	0.057 ± 0.224	F = 0.191, p = 0.662
Right occipital lobe	+9, −88, −4	0.017 ± 0.236	−0.158 ± 0.264	F = 14.875, p < 0.001
Left occipital lobe	−8, −96, −18	0.217 ± 0.177	0.136 ± 0.158	F = 7.087, p = 0.009
Right middle temporal gyrus	+52, −11, −12	−0.102 ± 0.218	−0.127 ± 0.213	F = 0.392, p = 0.553
Left middle temporal gyrus	−62, −17, −7	−0.0071 ± 0.199	−0.024 ± 0.218	F = 0.187, p = 0.667
Right parietal white matter	+32, −27, +33	−0.147 ± 0.147	−0.141 ± 0.129	F = 0.073, p = 0.788
Right middle parietal gyrus	+59, −42, +9	−0.117 ± 0.25	−0.141 ± 0.25	F = 0.274, p = 0.602
Right precuneus	+8, −58, +14	0.019 ± 0.21	−0.039 ± 0.189	F = 2.504, p = 0.116
Right cerebellum	+41, −67, −22	−0.056 ± 0.243	−0.121 ± 0.24	F = 2.154, p = 0.145
Right prefrontal white matter	+18, +38, +1	−0.08 ± 0.15	−0.047 ± 0.156	F = 1.483, p = 0.226
Right frontal white matter	+18, −12, +42	−0.019 ± 0.146	−0.028 ± 0.164	F = 0.077, p = 0.782
Left frontal pole	−20, +62, −9	−0.193 ± 0.266	−0.0396 ± 0.158	F = 14.854, p < 0.001
Left anterior cingulate	−11, +45, +17	−0.046 ± 0.255	−0.086 ± 0.228	F = 0.848, p = 0.359

The cluster in the ventral medial PFC (MNI coordinates: +0, +23, −24) was omitted from these analyses because it was located on the midline.