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. 2012 Jun 6;32(23):7917–7925. doi: 10.1523/JNEUROSCI.0307-12.2012

Table 5.

Criteria 2 and 3 for SWM total errors Z-scores, cumulative life stress, and prefrontal regions of interest [DV was SWM total errors Z-scores (higher z-score = fewer errors)]

Variables Unstandardized regression coefficients, SE, p value FΔ(df) R2 change, p values
Model 1
    Pubertal status B = 0.009, SE = 0.112, p = 0.937 FΔ (2,41) = 5.933 R2Δ = 0.224, p = 0.005
    Cumulative life stress B = −0.245, SE = 0.072, p = 0.002
Model 2
    Pubertal status B = 0.072, SE = 0.101, p = 0.481 FΔ (2,39) = 8.037 R2Δ = 0.226, p = 0.001
    Cumulative life stress B = −0.038, SE = 0.082, p = 0.647
    Frontal gray matter (left anterior cingulate cluster) B = 1.37, SE = 0.532, p = 0.014
    Frontal white matter (right prefrontal white matter cluster) B = 2.834, SE = 0.925, p = 0.004

Criterion 2 requires that the IV (cumulative life stress) is significantly associated with the DV (SWM performance) in the absence of the mediator. Criterion 3 requires that the mediator (prefrontal regions of interest) has a significant unique effect on the DV after adjusting for the IV, and the effect of the IV on the DV is reduced after the addition of the mediator to the model.