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. 2012 May 30;32(22):7563–7571. doi: 10.1523/JNEUROSCI.0069-12.2012

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Copyright © 2012 the authors 0270-6474/12/327563-09$15.00/0

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Figure 4. — Chronic GR blockade by mifepristone prevented the escalation of alcohol intake and motivation for alcohol in vapor-exposed animals during acute alcohol withdrawal. a, Timeline of the experiment. Dependent and nondependent rats were implanted with pellets for the chronic release of the GR antagonist mifepristone (150 mg for 21 d) or placebo before exposure to alcohol vapor. Mifepristone-treated vapor-exposed rats did not exhibit an escalation of alcohol intake (b) or increased PR responding (c) compared with placebo-treated vapor-exposed rats. Mifepristone did not influence alcohol intake in nondependent rats. The data represent mean and SE. *p < 0.05, significant difference from mifepristone-treated vapor exposed rats; ⁺p < 0.05, significant difference from placebo-treated nondependent rats. n = 9–10 per group.