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. 2012 May 30;32(22):7563–7571. doi: 10.1523/JNEUROSCI.0069-12.2012

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Copyright © 2012 the authors 0270-6474/12/327563-09$15.00/0

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Figure 5. — Chronic GR blockade by mifepristone decreased escalated alcohol intake in vapor-exposed animals during protracted alcohol abstinence. a, Timeline of the experiment. The rats were made dependent on alcohol by exposure to chronic, intermittent vapor exposure and then removed from the vapor chambers. One week later, dependent and nondependent rats were implanted with pellets for the chronic release of the GR antagonist mifepristone (150 mg for 21 d) or placebo. Behavioral testing began 1 week after pellet implantation (3 weeks of protracted withdrawal). Mifepristone-treated vapor-exposed rats did not exhibit escalated alcohol intake (b) or increased PR responding (c) compared with placebo-treated vapor-exposed rats. Mifepristone did not influence alcohol intake in nondependent rats. The data represent mean and SE. *p < 0.05, significant different from mifepristone-treated dependent rats and placebo-treated nondependent rats. n = 5–7 per group.