FIG. 2.
Ordered p-values in brains and examples of the coefficient functions. (A, B) Ordered p-values from VERSE for the upstream and downstream intronic regions in brains. The y-axis is the absolute log transform of regression p-values, and the x-axis is the ranks of the hexamers. The top 10 ranked motifs in both regions are listed. (C, D) Coefficient functions of TGCATG for the downstream intronic regions in brains and muscles. The x-axis is the baseline preference from the phyloP conservation score. The larger values near 1 indicate the conserved TGCATG sites, while smaller values near −1 are the newly evolved ones. The p-values for TGCATG are as low as 2.4 × 10−7 and 1.1 × 10−8, respectively, indicating significant associations with exon inclusion rates.