Table 3:
Sensitivity, specificity, positive (PPV) and negative predictive value (NPV) of 12-h values of procalcitonin, interleukin-6 and hs-CRP,determined by ROC analysis using the Youden’s index for optimal cut-off values in neonates with blood-culture-positive and clinical sepsis compared to neonates with negative infectious status.
| Diagnostic test | Cut-off | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | Youden |
|---|---|---|---|---|---|---|
| Procalcitonin(ng/ml) | ≥1.7 | 76.6 | 78.2 | 93 | 72 | 0.684 |
| ≥4.7 | 72 | 80.4 | 76 | 70 | 0.437 | |
| Interleukin-6(pg/ml) | ≥60 | 54 | 100 | 100 | 59 | 0.543 |
| ≥10 | 71 | 65 | 76 | 60 | 0.366 | |
| ≥150 | 46 | 100 | 100 | 55 | 0.457 | |
| hs-C-reactive protein(mg/L) | ≥2.5 | 69 | 96 | 96 | 67 | 0.642 |
| ≥8 | 49 | 100 | 100 | 58 | 0.486 |