Table 1.

NMR spectroscopic data for sanctolide A (1) in CDCl₃

		sanctolide A (1)
		δCa,c	δHb,c	mult.(J in Hz)	COSYb	HMBCb	NOESYb,d
1		174.5
2		38.1	2.56	m	3, 13	1, 3, 4, 13	3b, 4a, 13, 22
3	a	29.2	1.21	m	2, 4	1, 2, 4, 5, 13	3b, 4b, 13
	b		1.68	m			2, 3a, 4a, 5
4	a	34.1	1.42	m	3, 5	2, 3	3b, 4b, 13
	b		1.86	m			3a, 4a, 5, 13
5		73.3	5.00	m	4, 6	3, 4, 6, 7, 14	3a, 3b, 4a, 4b, 6a, 6b, 7, OMe
6	a	40.3	1.59	ddd (14.4, 9.0, 4.2)	5, 7	4, 5, 7, 8	4a, 4b, 6b, 7, OMe
	b		1.74	ddd (14.4, 7.8, 3.0)			6a, 5, 7, 8a, 8b
7		77.7	3.12	m	6, 8	5, 6, O-Me	5, 6a, 6b, 7, 8a, 8b
8	a	33.2	1.37	m	7, 9	6, 7, 9, 10	6a, 6b, 8b
	b		1.50	m			6b, 7, 8a, OMe
9		32.0	1.24	m	8, 10	7, 8, 10, 11
10		24.3	1.24	m	9, 11	8, 9, 11, 12
11		22.6	1.28	m	10, 12	9, 10, 12
12		14.2	0.87	t (7.1)	11	10, 11
13		14.9	1.13	d (6.9)	2	1, 2, 3	2, 3a, 4a, 4b
14		170.0
15		77.0	5.11	d (6.4)	16	14, 16, 17, 18, 19	16, 17, 18
16		29.6	2.31	sd (6.8, 6.4)	15, 17, 18	14, 15, 17, 18	15, 17, 18
17		18.6	0.94	d (6.8)	16, 18	15, 16, 18
18		17.2	0.90	d (6.8)	16, 17	15, 16, 17
19		168.7
20		34.5	3.15	dd (6.5, 1.3)	21	19, 21, 22	21, 22
			3.20	d (6.9)
21		102.7	5.12	m	20	19, 20, 22	20, 22, NMe
22		132.4	6.70	d (14.0)	21	1, 20, N-Me	2, 3b, 20, 21, NMe
O-Me		56.6	3.28	s		7	5, 6a, 8a, 8b, 17
N-Me		30.6	3.06	s		1, 22	21, 22

^aassigned using the DEPT-Q spectrum recorded at 226 MHz,

^brecorded at 600 MHz,

^cchemical shifts were referenced to the CDCl₃ solvent signals (δ_H 7.24 and δ_C 77.2)

^dmixing time: 600 ms