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Scope of the one-pot cyclopentane synthesis with diazoacetates 8.
 | |||||
|---|---|---|---|---|---|
| entry | comp. | R | yielda (%) |
drb | eec (%) |
| 1 | a | p-CF3C6H4 | 63 | > 20 : 1 | 78 |
| 2 | b | p-(OMe)C6H4 | 94 | > 20 : 1 | 87 |
| 3 | c | p-BrC6H4 | 48 | > 20 : 1 | 92 |
| 4 | d | Et | 63 | > 20 : 1 | 64 |
Isolated yield.
Determined from 1H NMR of crude reaction mixture.
Determined by chiral HPLC.
