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. Author manuscript; available in PMC: 2012 Jun 15.
Published in final edited form as: Drug Deliv Transl Res. 2011 Jun 1;1(3):209–222. doi: 10.1007/s13346-011-0022-6

Figure 3.

Figure 3

H9+ cells were incubated for 18 hrs in the absence or presence of 1 μM or 10 μM of dapivirine or UC781. The cells were washed extensively with culture medium to remove exogenous drug and then were co-cultured with uninfected MT-2 cells. The extent of viral infection of the MT-2 cells was determined after three days of co-culture by visual comparison of CPE relative to cells that were not treated with either compound. Dapivirine pre-treatment of MT-2/H9+ cell co-cultures resulted in 70% reduction in CPE levels compared to control MT-2/H9+ co-cultures. Dapivirine can inhibit HIV-1 cell to cell transmission.