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. Author manuscript; available in PMC: 2012 Jun 15.
Published in final edited form as: Drug Deliv Transl Res. 2011 Jun 1;1(3):209–222. doi: 10.1007/s13346-011-0022-6

Figure 7.

Figure 7

Dapivirine and placebo films were dissolved in 2 ml saline and serial dilutions made. The active pharmaceutical ingredient (API) was dissolved in DMSO and serial dilutions made. The dilutions were applied to the TZM-bl cells in triplicate with HIV-1BaL. After 48 hours, HIV-1 infection was measured by adding BrightGlo (Promega) to the plates and reading for luminescent activity. The data show the API with an IC50 of 7.9 nM and the Dapivirine film with an IC50 of 38.3 nM. Minimal anti-HIV-1 activity was associated with the film.