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Calculated permeability parameters of dapivirine drug substance
| Tissue # | 1.25 mg Dapivirine film | Dapivirine drug substance | ||
|---|---|---|---|---|
| Mean | SD | Mean | SD | |
| 1 | 1.66E-06 | 6.22E-07 | 3.66E-06 | 9.76E-07 |
| 2 | 2.19E-06 | 2.81E-07 | 2.1E-06 | 1.78E-06 |
| 3 | 1.15E-06 | 2.53E-07 | 3.04E-06 | 8.29E-07 |
Legend:
Apparent permeability values Papp (cm/sec) for dapivirine drug substance and 1.25 mg dapivirine film. For each tissue sample, permeability testing was done in triplicate. Values presented as mean ± SD.
