Table I.

A Comparison of Measured and Summed Secondary Structure Content of MeCP2

	0% TFE			20% TFE			50% TFE			70% TFE
	%Ua	%αb	%βc	%U	%α	%β	%U	%α	%β	%U	%α	%β
Measuredd	68	8	24	37	31	33	34	42	26	23	56	23
Summede	65	6	28	45	20	34	34	34	33	27	43	30

^a% Unstructured residues.

^b% α-helical residues.

^c% β-sheet/turn residues.

^dTaken from Figure 2(B).

^eFor each TFE concentration, the measured % U, %α, and %β values for the NTD, MBD, ID, TRD, and CTD were multiplied by 0.16, 0.18, 0.08, 0.2, and 0.38, respectively (the fraction of the total protein sequence corresponding to each domain). The resulting values were then summed.