Table 2.
Numerical values and statistical comparisons of fibrinogen, and fibrinolytic system proteins before pregnancy and during pregnancy.
| Prepregnancy | Early Pregnancy† | Late Pregnancy | p-value# | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Variable | CTL | CH | CTL | CH | CTL | CH | Assessment Time |
Pregnancy Group |
Time by Group Interaction |
|
|
Coagulation System |
||||||||||
| Fibrinogen | 223 ± 12 | 199 ± 21 | 360 ± 17 | 318 ± 24 | 473 ± 27 | 330 ± 129 | <.001 | .07 | .17 | |
|
Fibrinolytic System |
||||||||||
| D-Dimer | 0.26 ± 0.04 | 0.3 ± 0.08 | 0.49 ± 0.06 | 0.45 ± 0.04 | 0.97 ± 0.10 | 0.96 ± 0.25 | <.001 | .99 | .96 | |
| PAI-1 Antigen |
17.3 ± 5.7 | 20.1 ± 10.5 | 17.7 ± 1.9 | 24.7 ± 3.2 | 66.4 ± 4.9 | 57.7 ± 12.9 | <.001 | .96 | .68 | |
| PAI-1 Activity | 9.3 ± 1.9 | 6.1 ± 1.7 | 9.0 ± 0.8 | 8.9 ± 2.6 | 31.4 ± 3.0 | 30.0 ± 3.1 | <.001 | .65 | .91 | |
| T-PA | 4.2 ± 0.4 | 3.2 ± 0.3 | 3.6 ± 0.2 | 4.1 ± 0.5 | 5.0 ± 0.22 | 8.1 ± 0.69 | <.001 | .10 | .001 | |
#
Significance levels based on repeated measures analyses of variance
†
One control subject missed her first trimester study day. Therefore, the first trimester measurements only include 16 women.