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. Author manuscript; available in PMC: 2012 Jun 15.
Published in final edited form as: Diabetes Obes Metab. 2008 Nov;10(0 4):23–31. doi: 10.1111/j.1463-1326.2008.00939.x

Table 1.

Summary of autopsy studies that examined β-cell mass in patients with recent-onset T1DM

References N (M/F) Duration of
diabetes		 Reported decrease in β-cell mass in recent-onset T1DM
Gepts 1965 [12] 12/10 T1DM, 26 ND 3–180 days ~90–100% decrease in β-cell numbers per section area vs. ND controls
Gepts and De Mey 1978 [13] 7/9 T1DM 3–90 days ~90–100% decrease in β-cell numbers per section area vs. ND control
Kloppel et al. 1984 [9] 1 T1DM, 4 ND ~7 days ~80% decrease in β-cell volume vs. ND controls
Lernmark et al. 1995 [10] 1/1 T1DM, 9 ND 0–4 weeks ~80% decrease in β-cell islet volume density vs. ND controls
Butler et al. 2007 [15] 2/5 T1DM, 6/3 ND 0–3 years ~90% decrease in β-cell area vs. ND controls

Abbreviations: T1DM, type 1 diabetes; ND, non-diabetic.