Table 1.
Characteristics of Study Subjects with Different Categories of Glucose Tolerance
| Characteristic | All Patients (N=97) |
NGT (N=61) |
IFG (N=20) |
IGT (N=7) |
IFG/IGT (N=9) |
*P- Value |
|---|---|---|---|---|---|---|
| Age (mean±SD), years | 48±7 | 48±7 | 48±7 | 49±7 | 51±4 | 0.5 |
| Male Sex (N, (%)) | 70 (72) | 44 (72) | 16 (80) | 5 (71) | 5 (56) | 0.6 |
| Race/Ethnicity† (N, (%)) Caucasian African-American Hispanic/Latino Other |
43 (44) 20 (21) 27 (28) 7 (7) |
38 (62) 10 (16) 8 (13) 5 (8) |
3 (15) 5 (25) 10 (50) 2 (10) |
1 (14) 3 (43) 3 (43) -- |
1 (11) 2 (22) 6 (67) -- |
0.002 |
| BMI (mean±SD), kg/m2 | 27±5 | 26±4 | 28±5 | 28±3 | 30±4 | 0.01 |
| Current Alcohol Consumption (N, (%)) | 26 (27) | 17 (28) | 6 (30) | 2 (29) | 1 (11) | 0.7 |
| Diabetes Family History (N, (%)) | 43 (44) | 26 (43) | 11 (55) | 2 (29) | 4 (44) | 0.6 |
| HCV Viral Load (mean±SD), log10 IU/mL | 6±0.7 | 6±0.7 | 6±0.4 | 5±1.2 | 6±0.8 | 0.4 |
| HCV Genotype (N) Genotype 1 (N, (%)) Genotype 2 (N, (%)) Genotype 3 (N, (%)) |
95 65 (68) 16 (17) 14 (15) |
60 42 (70) 12 (20) 6 (10) |
20 13 (65) 3 (15) 4 (20) |
6 3 (50) 1 (17) 2 (33) |
9 7 (78) -- 2 (22) |
0.5 |
| Duration of HCV Infection (mean±SD), years | 26±10 | 26±10 | 27±9 | 28±10 | 26±8 | 1.0 |
| Liver Biopsy Findings (N) Inflammation Grade ≥ 2 (N, (%)) Fibrosis Score ≥ 2 (N, (%)) Steatosis (N, (%)) |
77 48 (62) 34 (44) 27 (35) |
52 29 (56) 20 (38) 15 (29) |
14 12 (86) 9 (64) 6 (43) |
5 2 (40) 1 (20) 2 (40) |
6 5 (83) 4 (67) 4 (67) |
0.1 0.1 0.3 |
| ALT (mean±SD), units/L | 93±85 | 97±88 | 76±52 | 57±19 | 127±134 | 0.4 |
| Ferritin (mean±SD), ng/mL | 172±152 | 174±166 | 155±87 | 130±99 | 228±197 | 0.7 |
| Total cholesterol (mean±SD), mg/dL | 172±40 | 175±38 | 169±54 | 179±22 | 157±26 | 0.4 |
| LDL (mean±SD), mg/dL | 101±34 | 104±28 | 99±49 | 112±16 | 74±29 | 0.01 |
| HDL (mean±SD), mg/dL | 50±13 | 50±12 | 54±12 | 46±9 | 48±21 | 0.4 |
| Triglycerides (mean±SD), mg/dL | 103±53 | 102±55 | 97±45 | 100±31 | 127±71 | 0.6 |
*
P values are for comparison of all four groups of glucose tolerance (NGT, IFG, IGT, and IFG/IGT) and P <0.05 (2-sided) is considered statistically significant.
†
By self-report.
BMI, body mass index; HCV, hepatitis C virus; ALT, alanine aminotransferase; LDL, low-density lipoprotein; HDL, high-density lipoprotein.