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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: J Viral Hepat. 2011 Dec 18;19(7):480–487. doi: 10.1111/j.1365-2893.2011.01568.x

Table 2.

Insulin Sensitivity and Secretion in Study Subjects with NGT or Pre-Diabetes

Characteristic NGT
(N=61)		 IFG
(N=20)		 IGT
(N=7)		 IFG/IGT
(N=9)		 *P-
Value
Fasting Glucose (mean±SD),
mg/dL		 90±7 106±5 89±7 112±8 <0.0001
2-Hour Glucose on OGTT
(mean±SD), mg/dL		 97±21 112±16 151±18 166±14 <0.0001
Fasting Insulin (mean±SD),
µIU/mL		 14±6 17±9 19±16 25±17 0.2
SSPG (median (min-max)),
mg/dL		 98 (39–298) 111 (63–307) 204 (57–275) 206 (135–328) 0.01
SSPI (median (min-max)),
microIU/mL		 70 (44–134) 71(37–148) 98 (54–165) 80 (38–108) 0.5
G-AUC (mean±SD) 336±44 387±27 423±39 473±67 <0.0001
I-AUC (mean±SD) 167±97 212±139 248±135 274±123 0.04
†Early Insulin Secretory
Response (mean±SD)
[ΔI0–30/ΔG0–30]		 1.65±1.95 1.11±0.75 0.91±0.74 1.29±0.74 0.3
Early Insulin Secretory
Response adjusted for
degree of insulin resistance
(mean±SD)
[ΔI0–30/∆G0–30] /SSPG		 0.015±0.013 0.009±0.009 0.006±0.004 0.006±0.004 0.01
Total Insulin Secretion
adjusted for degree of insulin
resistance (mean±SD)
[I-AUC/G-AUC]/SSPG		 0.005±0.003 0.004±0.002 0.004±0.001 0.003±0.001 0.02
*

P values are for all group comparisons and P <0.05 (2-sided) is considered statistically significant.

†

Insulinogenic index.

OGTT, oral glucose tolerance test; SSPG, steady-state plasma glucose; SSPI, steady-state plasma insulin; G-AUC, area under the curve of glucose response during OGTT; I-AUC, area under the curve of insulin response during OGTT.