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. Author manuscript; available in PMC: 2012 Jul 1.
Published in final edited form as: Kidney Int. 2011 Sep 28;81(2):152–159. doi: 10.1038/ki.2011.332

Figure 2. Tubular C3b/iC3b/C3d deposition in MRL/lpr mice reduces as the mice age.

Figure 2

(a) Representative images of tubular staining for C3b/iC3b in cortex (top panel), outer medulla (middle panel) and inner medulla (bottom panel) of MRL/lpr kidneys are presented. Similar images were obtained for C3d immunostaining (images not shown). Arrowheads point to glomeruli. (b) Changes in tubular C3b/iC3b deposition in MRL/lpr mice as the mice age. Quantification of RFU shows a trend towards a decrease in tubular C3b/iC3b or C3d staining with disease progression (ages 8, 16 and 22 weeks; n = 2 mice for C3d staining inner medulla of 8 weeks old mice and n = 3 mice per age group for all other conditions; RFU for each mouse is a mean RFU obtained from 10 randomly selected tubules from each kidney compartment; horizontal bars represent the mean RFU from all the mice in the respective age groups). Scale bar in (a) = 200 μm.