Figure 7.

Different fusion initiation modes. A) Primary action of PFOB prior to the protrusion of lipids. B) Protrusion of PFOB-NEP lipid in conjunction with PFOB molecules (solid red) C) Protrusion of lipids in the absence of PFOB molecules. D) Interaction among three molecules. Lipids and PFOBs that directly involved in the initial monolayer disruption are depicted in darker colors and thicker sticks and additional balls while the rest of the molecules are shown in thinner sticks and faint colors. PFOBs are shown in green and light green colors with the enclosing phospholipids in red and orange colors. The phospholipids of the liposomes are shown in blue and light blue.