Figure 2.

Reversal of ET-1-induced vasoconstriction. Vessels treated with ET-1 (0.1 nM) for 20 minutes constricted to a stable diameter, then were exposed to Ca²⁺-free solution (n = 6) or treated with 10 μM (n = 8) or 3 μM (n = 14) H-1152, nifedipine (1 μM, n = 6), or Gö-6983 (3 μM, n = 8) for 20 minutes. R, resting diameter of vessels. *P < 0.05 versus percent resting diameter at R. #P < 0.05 for percent resting diameter values at 20 minutes versus percent resting diameter observed at time of addition of 0.1 nM ET-1 (0 minutes).