Figure 7.
Effect of agonists specific to histamine receptor subtypes on goblet cell glycoconjugate secretion. Cultured goblet cells from rats were incubated with the concentration of agonists that caused maximum secretion. The agonists used were histamine (10−5 M), the H1 receptor agonist histamine dimaleate (10−6 M), the H2 receptor agonist amthamine (10−4 M), the H3 receptor agonist α-methylhistamine (10−5 M), and the H4 receptor agonist 4-methylhistamine (10−5 M) for 2 hours. Glycoconjugate secretion was measured by enzyme-linked lectin assay. Data are mean ± SEM of seven independent experiments. * indicates statistical significance from no addition (0).