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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: Nanomedicine (Lond). 2012 Apr;7(4):597–615. doi: 10.2217/nnm.12.22

Figure 6. Targeted photodynamic nanotherapy.

Figure 6

(A) Synthesis of calcium phosphosilicate nanoparticles modified with CD117 mAb (CPSNP-CD117). (B) Survival of mice with myeloid leukemia established with 32D-p210-GFP cells, was monitored after the treatment with phosphate-buffered saline, empty (ghost)-CPSNPs, CD117-targeted ghost-CPSNPs, ICG-CPSNPs, or CD117-targeted ICG-CPSNPs followed by near infrared laser treatment of the spleen. A log rank test indicated significance (p < 0.05) between the curves (group of seven).

CPSNP: Calcium phosphosilicate nanoparticle; EDC: Ethyl(dimethylaminopropyl) carbodiimide; ICG: Indocyanine green; NHS: N-hydroxysuccinimide; PEG: Polyethylene glycol.

Reproduced with permission from [62].