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. 2012 Jun 15;7(6):e39151. doi: 10.1371/journal.pone.0039151

Figure 1. MiR-127 was prominently down-regulated at 24 h after partial hepatectomy (PH).

Figure 1

. (A) Scatter plot of miRNA expression in PH rats versus SH rats at 3 h post surgery quantified by miRNA microarray which contains 988 human, 627 mouse, and 350 rat miRNA probes. (B) Seven differentially expressed rat miRNAs were identified and ratio values >1.5 or <0.7 were considered up-regulated (red) or down-regulated (green) in PH rats compared to SH rats. MiR-127 was identified with at least 3-fold differences between the two groups. (C) The relative expression of miR-127 during liver regeneration by qRT-PCR analysis. (D) MiR-127 expression levels in rat liver tissues, primary hepatocytes, BRL-3A and Huh7 cells by qRT-PCR analysis. MiR-127 levels were normalized to that of U6. Data from three independent experiments are shown as the means ± SD. (*P<0.05, **P<0.01).