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. 2012 Jun 15;7(6):e39257. doi: 10.1371/journal.pone.0039257

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Chen et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) HL-60 cells were treated with 50 nM CHEC-9 or TBS vehicle for 4days with stimulation of PMA. The large increase of sPLA2 activity after differentiation was significantly attenuated by CHEC-9 treatment. (B) Differentiated SY5Y neuronal cells were subjected to medium change and serum deprivation for 2days. Compared with vehicle group, CHEC-9 treatments at 1 and 50 nM both reduced sPLA2 activity, but this change just missed significance (p = 0.07). (C, D) cPLA2 and iPLA2 activity of HL-60 cell homogenates. There was no difference between the undiffentiated and differntaited HL-60 cells. CHEC-9 treatment did not show inhibition of the cPLA2 or iPLA2 activities.