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. 2012 Jun 15;7(6):e38885. doi: 10.1371/journal.pone.0038885

Figure 1. Comparison of 12 miRNAs expression levels between sepsis non-survivors and survivors in a validation set.

Figure 1

Differentially expressed miRNAs identified by Solexa sequencing were validated by qRT-PCR in sepsis survivors (S; N = 15) compared to non-survivors (D; N = 15). MiR-16 (p = 0.005), miR-15a (p = 0.021), miR-223 (p = 0.015), miR-483-5p (p<0.001), miR-193b* (p<0.001), miR-122 (p<0.001), and miR-499-5p (p = 0.006) were significantly different after validation with qRT-PCR. Expression levels of the 12 miRNAs were normalized to U6 snRNA above normal controls and given as fold-changes (2–ΔΔCt ). △△Ct  =  (CtmiRNA-CtU6 snRNA) patients-(CtmiRNA-CtU6 snRNA)controls. Mann-Whitney U-test was used for statistical comparisons.