Example views from four patients undergoing both standard MBI and low-dose screening MBI with approximately 2–3 yr between exams. On the top row, standard 10 min/view MBI was performed with a 740 MBq injection, standard collimator, and standard energy window. On the bottom row, low-dose 10 min/view MBI was performed using either 148 or 296 MBq injection, optimized collimation, and wide energy window. All images were interpreted as negative.