MBI study acquired for 10 min following 740 MBq injection Tc-99 m sestamibi, using standard collimation, and (a) wide energy window (110–154 keV), (b) standard energy window (126–154 keV). The difference of images in panels (a) and (b) is shown in panel (c). Each image is displayed on the range from its individual minimum to maximum count. Count density in this patient was improved by a factor of 2.6 with the wider energy window, A 1.3 cm × 1.0 cm × 0.9 cm invasive ductal carcinoma was detected, and the wide energy window resulted in improved detection of an extension of ductal carcinoma in situ (see arrow).