Table III.
Distribution of cytokine genotypes in cases with chlamydial TFI and controls.
| Gene, SNP |
n (%) |
P-test of proportion | χ2 for trend (P-value) | OR (95% CI) | |
|---|---|---|---|---|---|
| TFI women | Controls | ||||
| IL12A, rs2243123 | |||||
| TT | 53 (55.2) | 64 (54.2) | 0.887 | 0.868 | Reference |
| CT | 35 (36.5) | 47 (39.8) | 0.614 | 0.90 (0.51–1.59) | |
| CC | 8 (8.3) | 7 (5.9) | 0.494 | 1.38 (0.47–4.06) | |
| IL12A, rs583911 | |||||
| AA | 33 (38.8) | 34 (32.1) | 0.331 | 0.468 | Reference |
| AG | 33 (38.8) | 47 (44.3) | 0.443 | 0.72 (0.38–1.39) | |
| GG | 19 (22.4) | 25 (23.6) | 0.841 | 0.78 (0.36–1.68) | |
| IL12A, rs568408 | |||||
| GG | 73 (76.8) | 89 (73.6) | 0.58 | 0.664 | Reference |
| AG | 18 (18.9) | 27 (22.3) | 0.545 | 0.81 (0.42–1.59) | |
| AA | 4 (4.2) | 5 (4.1) | 0.977 | 0.98 (0.25–3.77) | |
| IL12B, rs3212227 | |||||
| AA | 66 (69.5) | 89 (84.0) | 0.015 | 0.028 | Reference |
| AC | 29 (30.5) | 16 (15.1) | 0.009 | 2.44 (1.23–4.87) | |
| CC | 0 (0) | 1 (0.9) | 0.343 | ||
| IL12B rs11574790 | |||||
| CC | 86 (86.9) | 106 (84.8) | 0.66 | 0.858 | Reference |
| CT | 10 (10.1) | 19 (15.2) | 0.259 | 0.65 (0.29–1.47) | |
| TT | 3 (3.0) | 0 (0) | 0.05 | ||
| IL12B rs919766 | |||||
| AA | 85 (85.9) | 106 (84.8) | 0.824 | 0.716 | Reference |
| AC | 11 (11.1) | 19 (15.2) | 0.372 | 0.72 (0.33–1.60) | |
| CC | 3 (3.0) | 0 (0) | 0.05 | ||
| IL12B rs2853694 | |||||
| CC | 31 (32.6) | 36 (31.0) | 0.804 | 0.782 | Reference |
| AC | 41 (43.2) | 57 (49.1) | 0.386 | 0.84 (0.45–1.56) | |
| AA | 23 (24.2) | 23 (19.8) | 0.443 | 1.16 (0.55–2.46) | |
| IL12B rs2569253 | |||||
| CC | 28 (34.1) | 48 (45.3) | 0.123 | 0.095 | Reference |
| CT | 41 (50.0) | 47 (44.3) | 0.441 | 1.50 (0.80–2.80) | |
| TT | 13 (15.9) | 11 (10.4) | 0.265 | 2.03 (0.80–5.13) | |
| IL12B rs1003199 | |||||
| TT | 31 (31.6) | 48 (41.4) | 0.141 | 0.315 | Reference |
| CT | 52 (53.1) | 50 (43.1) | 0.146 | 1.61 (0.89–2.92) | |
| CC | 15 (15.3) | 18 (15.5) | 0.966 | 1.29 (0.57–2.93) | |
| IL12B rs6887695 | |||||
| GG | 58 (58.6) | 70 (56.5) | 0.749 | 0.856 | Reference |
| CG | 34 (34.3) | 46 (37.1) | 0.67 | 0.89 (0.51–1.57) | |
| CC | 7 (7.1) | 8 (6.5) | 0.855 | 1.06 (0.36–3.09) | |
The two-sample test of proportions was performed to compare genotype frequencies in cases and controls. A χ2 test for trend was used to analyse a possible trend between disease and genotype. ORs with 95% CIs are shown.