Table 1.
Interaction between DRD1 and CHRNA5-CHRNA3-CHRNB4 Chromosome 15 nAChR region SNPs and nicotine metabolism rate (slow vs. normal metabolizers) on abstinence at end of treatment.
| Haplotype | Slow Metabolizer | Normal Metabolizer | Interaction P-value | ||
|---|---|---|---|---|---|
| SNP | Block | OR (95% CI)a | OR (95% CI)a | Observed | Adjustedb |
| DRD1 | |||||
| rs1310277 | 1 | 1.98 (1.03 – 3.83) | 0.53 (0.32 – 0.87) | 1.32 × 10−3 | 2.26 × 10−2 |
| rs10476156 | 3 | 2.05 (1.10 – 3.80) | 0.64 (0.41 – 1.00) | 1.25 × 10−3 | 2.22 × 10−2 |
| rs4867796 | b/w 4–5 | 2.75 (1.53 – 4.94) | 0.91 (0.61 – 1.37) | 1.48 × 10−3 | 2.40 × 10−2 |
| rs11746641 | 5 | 3.10 (1.67 – 5.79) | 0.82 (0.53 – 1.25) | 2.06 × 10−4 | 4.05 × 10−3 |
| rs2168631 | 5 | 3.30 (1.75 – 6.22) | 0.87 (0.58 – 1.30) | 1.96 × 10−4 | 3.96 × 10−3 |
| rs11749035 | 5 | 3.49 (1.84 – 6.67) | 0.79 (0.52 – 1.21) | 5.95 × 10−5 | 1.25 × 10−3 |
| CHRNA5-CHRNA3-CHRNB4 | |||||
| rs2036527 | 1 | 1.52 (0.94 – 2.45) | 0.81 (0.59 – 1.11) | 3.88 × 10−2 | 2.85 × 10−1 |
| rs1051730 | 2 | 1.54 (0.95 – 2.48) | 0.85 (0.62 – 1.16) | 4.23 × 10−2 | 2.99 × 10−1 |
| rs1317286 | 2 | 1.50 (0.92 – 2.44) | 0.85 (0.62 – 1.16) | 4.81 × 10−2 | 3.24 × 10−1 |
| rs7178270 | 3 | 0.46 (0.23 – 0.91) | 1.07 (0.68 – 1.68) | 3.37 × 10−2 | 2.57 × 10−1 |
a
Odds Ratio of quitting associated with minor allele at SNP in specific NMR group
b
P-value corrected for the correlation structure within respective gene region