Table 4.
Table 4a. Canonical pathway | Gene | p-value |
---|---|---|
GABA receptor signaling | GABRA4, GABRG3, GAD1 | 2.03E-03 |
Agrin interactions at neuromuscular junctions | NRG1, NRG3, ERBB4 | 5.55E-03 |
Dopamine receptor signaling | COMT, DRD3, PPP2R2C | 7.87E-03 |
Neuregulin signaling | NRG1, NRG3, ERBB4 | 1.10E-02 |
Neuropathic pain signaling in dorsal horn neurons | BDNF, CAMK2D, GRIN2B | 1.61E-02 |
B cell activating factor signaling | IKBKAP, TRAF3 | 1.94E-02 |
cAMP-mediated signaling | CAMK2D, DRD3, HTR7, OPRD1 | 2.71E-02 |
Lymphotoxin β receptor signaling | IKBKAP, TRAF3 | 3.39E-02 |
Glutamate receptor signaling | GRIN2B, GRID2 | 3.63E-02 |
Activation of IRF by cytosolic pattern recognition receptors | IKBKAP, TRAF3 | 4.11E-01 |
CD40 signaling | IKBKAP, TRAF3 | 4.36E-01 |
Table 4b. Functional annotation cluster | Gene | p-value |
---|---|---|
Synapse | GABRA4, GABRG3, GAD1, GRIN2B, GRID2, ERBB4, SHC4, OTOF, PSD3, CTBP2 | 5.20E-03 |
Cell projection (axon, dendrite, flagellum, etc.) | DRD3, GAD1, GRIN2B, MYCBP2, DNAH11, WNT2, ESR1, CDH13, ALCAM, MYO5A | 9.70E-02 |
Note: 4 neurotransmitter signaling pathways are extracted from Ingenuity pathway knowledge base. David bioinformatics resource identifies the most significant cluster to be functionally related to synapse, while another marginally significant cluster relating to cell projection.