Table 4.

Biological pathway analysis and functional annotation clustering

Table 4a. Canonical pathway	Gene	p-value
GABA receptor signaling	GABRA4, GABRG3, GAD1	2.03E-03
Agrin interactions at neuromuscular junctions	NRG1, NRG3, ERBB4	5.55E-03
Dopamine receptor signaling	COMT, DRD3, PPP2R2C	7.87E-03
Neuregulin signaling	NRG1, NRG3, ERBB4	1.10E-02
Neuropathic pain signaling in dorsal horn neurons	BDNF, CAMK2D, GRIN2B	1.61E-02
B cell activating factor signaling	IKBKAP, TRAF3	1.94E-02
cAMP-mediated signaling	CAMK2D, DRD3, HTR7, OPRD1	2.71E-02
Lymphotoxin β receptor signaling	IKBKAP, TRAF3	3.39E-02
Glutamate receptor signaling	GRIN2B, GRID2	3.63E-02
Activation of IRF by cytosolic pattern recognition receptors	IKBKAP, TRAF3	4.11E-01
CD40 signaling	IKBKAP, TRAF3	4.36E-01

Table 4b. Functional annotation cluster	Gene	p-value
Synapse	GABRA4, GABRG3, GAD1, GRIN2B, GRID2, ERBB4, SHC4, OTOF, PSD3, CTBP2	5.20E-03
Cell projection (axon, dendrite, flagellum, etc.)	DRD3, GAD1, GRIN2B, MYCBP2, DNAH11, WNT2, ESR1, CDH13, ALCAM, MYO5A	9.70E-02

Note: 4 neurotransmitter signaling pathways are extracted from Ingenuity pathway knowledge base. David bioinformatics resource identifies the most significant cluster to be functionally related to synapse, while another marginally significant cluster relating to cell projection.