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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: Bioorg Med Chem Lett. 2012 May 8;22(13):4413–4417. doi: 10.1016/j.bmcl.2012.04.126

Table 3.

Ester Analogs

Compound R2 aMax Inh EC50 (μM)
1 graphic file with name nihms-376117-t0017.jpg 0.82 2.3
11a graphic file with name nihms-376117-t0018.jpg 0.80 3.9
11b graphic file with name nihms-376117-t0019.jpg 0.85 bNT
11c graphic file with name nihms-376117-t0020.jpg 0.75 3.0
11d graphic file with name nihms-376117-t0021.jpg 0.79 2.5
11e graphic file with name nihms-376117-t0022.jpg 0.70 8.8
11f graphic file with name nihms-376117-t0023.jpg 0.45 5.5
11g graphic file with name nihms-376117-t0024.jpg 0.50 4.0
11h graphic file with name nihms-376117-t0025.jpg 1.0 NT
11i graphic file with name nihms-376117-t0026.jpg 0.40 7.8
11j graphic file with name nihms-376117-t0027.jpg 0.30 7.4
11k graphic file with name nihms-376117-t0028.jpg 0.33 1.8
11l graphic file with name nihms-376117-t0029.jpg 0.40 2.6
11m graphic file with name nihms-376117-t0030.jpg 0.50 2.5
a

results are average of 2 or more experiments.

Value = fold change relative to DMSO control at 10 μM compound;

b

NT = not tested. .

All standard deviations ≤ 25%.