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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: Bioorg Med Chem Lett. 2012 May 8;22(13):4413–4417. doi: 10.1016/j.bmcl.2012.04.126

Table 4.

Pipendine and Pyrrolidine Analogs

Compound R2 aMax Inh EC50 (μM)
11k graphic file with name nihms-376117-t0031.jpg 0.33 1.8
11n graphic file with name nihms-376117-t0032.jpg 0.80 bNT
11o graphic file with name nihms-376117-t0033.jpg 0.90 NT
11p graphic file with name nihms-376117-t0034.jpg 0.31 NT
11q graphic file with name nihms-376117-t0035.jpg 0.14 NT
11r graphic file with name nihms-376117-t0036.jpg 0.24 1.6
a

results are average of 2 or more experiments.

Value = fold change relative to DMSO control at 10 μM compound;

b

NT = not tested. .

All standard deviations ≤ 25%.