. Author manuscript; available in PMC: 2013 Jul 1.

Published in final edited form as: Bioorg Med Chem Lett. 2012 May 8;22(13):4413–4417. doi: 10.1016/j.bmcl.2012.04.126

Table 6.

In vivo properties of selected Rev-erbα agonists

Compound	^a[Plasma] (μM)	[Brain] (μM)	^eb.p. (%)
^b 1	0.25	0.35	140
^b 12h	0.53	0.24	53
^b 12j	0.54	1.3	242
^b 12e	0.53	0.53	100
^c 12e	6.7	^d8.7	100

Mice sacrificed at t = 2h. Brain and plasma levels of drug determined;

Mice dosed 10 mg/kg IP in 10:10:80 DMSO:Tween:water;

Mice dosed 50 mg/kg IP in 15% cremaphor EL;

brain levels at 8h;

b.p. = brain penetration.