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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: Pharmacogenet Genomics. 2012 Jul;22(7):525–537. doi: 10.1097/FPC.0b013e32835366f6

Fig. 3.

Fig. 3

Kinetics of COX inhibition by aspirin in wildtype PGHS-1 and variants. A) Decay of COX activity during preincubation with 1.0 mM aspirin. Lines represent fits for single exponential decay. B) Effect of aspirin level on COX decay rate during preincubation. Each data point represents the fitted decay rate for a separate experiment with the indicated aspirin level and at least five different lengths of preincubation. Rate constants were corrected for control COX decay rates in absence of aspirin. Lines represent linear fits.