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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: Pharmacogenet Genomics. 2012 Jul;22(7):525–537. doi: 10.1097/FPC.0b013e32835366f6

Fig. 5.

Fig. 5

Effect of NS398 on kinetics of COX inactivation by aspirin in PGHS-1 wildtype (WT) and R108Q variant. Each enzyme was preincubated with 1.0 mM aspirin and the indicated levels of NS-398 for varying lengths of time to determine apparent rate constants (k2’) for loss of COX activity. The k2’ vs. [NS-398] data from each experiment were analyzed to estimate IC50 values as described in Methods. The IC50 values shown are averages ± SD from 3-4 experiments.