Table II.
Regional brain activity in response to bladder filling (main effects).
| Region | Coordinates | T- | Z- | Cluster | |||
|---|---|---|---|---|---|---|---|
| x | y | z | value | Value | level | ||
| 1. | A. Activations during reported urgency | ||||||
| Group with DO in the scanner | |||||||
| Precentral gyrus (BA6) | −58 | −6 | 38 | 8.45 | 4.18** | ¶¶¶c | |
| Medial frontal gyrus (BA 6) | 10 | −12 | 56 | 5.82 | 3 54* | ||
| Superior frontal gyrus ( BA6) | −10 | 16 | 58 | 5.66 | 3.49* | ||
| Inferior parietal lobe (BA 40) | −28 | −44 | 54 | 4.75 | 3.19* | ||
| Anterior cingulate gyrus (dorsal, BA 32) | −4 | 24 | 34 | 7.72 | 4.03** | ¶¶¶c | |
| Middle frontal gyrus (BA 10) | 34 | 40 | 10 | 6.84 | 3.82** | ¶¶¶c | |
| Insula (BA 13) | 32 | 20 | 4 | 5.90 | 3.57* | ¶¶¶c | |
| Inferior frontal gyrus (BA 47) | 38 | 30 | 6 | 6.84 | 3.82** | ¶¶¶c | |
| Cuneus (BA 18) | −4 | −88 | 12 | 4.45 | 3.07 | ||
| Cerebellum (posterior lobe) | −16 | −78 | −32 | 7.48 | 3.97** | ¶u | |
| Cerebellum (anterior lobe) | −38 | −48 | −28 | 5.38 | 3.40* | ¶u | |
| Group without DO in the scanner | |||||||
| Medial frontal gyrus (BA 6) | 6 | 2 | 58 | 2.98 | 2.68 | ||
| Superior frontal gyrus (BA 8) | −2 | 18 | 52 | 2.82 | 2.56 | ||
| Insula (BA 13) | 36 | 20 | 8 | 2.72 | 2.48 | ||
| Inferior frontal gyrus (BA 9) | 48 | 8 | 22 | 2.71 | 2.47 | ||
| Middle frontal gyrus (BA 9) | 38 | 22 | 34 | 2.98 | 2.68 | ||
| B. Deactivations during reported urgency | |||||||
| Group without DO in the scanner - | |||||||
| Fusiform gyrus | −26 | −38 | −14 | 4.59 | 3.75** | ¶u | |
| Parahippocampus (BA 19) | −28,28 | −50,−50 | −4,−6 | 3.55,3.55 | 3.09*,3.28* | ¶u, − | |
| Hippocampus | −36 | −12 | −14 | 3.83 | 3.28* | ||
| Occipital gyrus | −40 | −76 | 26 | 3.52 | 3.07 | ||
| Amygdala | −30 | −8 | −14 | 3.18 | 2.83 | ||
| C. Between group differences | |||||||
| Activations in DO group > no DO | |||||||
| Parietal lobe (precuneus, BA 19) | −18 | −78 | 40 | 5.10 | 4.29** | ||
| Fusiform gyrus (BA 37) | −32 | −46 | −12 | 3.70 | 3.33* | ||
| SMA/precentral gyrus (BA 4) | −18 | −20 | 60 | 3.64 | 3.28* | ¶¶¶u | |
| 2. | A. Activations with nearly empty bladder | ||||||
| Group with DO in the scanner | |||||||
| SMA (Superior Frontal gyrus, BA 6) | 14 | −8 | 66 | 6.76 | 3.80** | ||
| Temporal lobe (BA 41) | 52 | −20 | 12 | 4.71 | 3.17* | ||
| Middle frontal gyrus (BA 46) | −40 | 36 | 24 | 4.25 | 2.99 | ||
| Group without DO in the scanner | |||||||
| Postcentral gyrus (BA 2) | −56 | −22 | 32 | 5.97 | 4.27** | ¶c | |
| Claustrum/insula | 36,-36 | 0,−6 | −2,20 | 5.71,4.57 | 4.16**,3.60* | ¶¶c,¶c | |
| Inferior frontal gyrus (BA 47) | 42 | 24 | 0 | 5.24 | 3.94** | ¶¶c | |
| Superior frontal gyrus (BA 9) | −38 | 36 | 26 | 4.76 | 3.70* | ||
| Inferior parietal lobe (BA 40) | 50 | −36 | 48 | 4.56 | 3.60* | ¶c | |
| Medial frontal gyrus (BA 9) | −2 | 46 | 30 | 4.29 | 3.45* | ||
| B. Deactivations with nearly empty bladder | |||||||
| Group with DO in the scanner | |||||||
| ACG (subgenual; BA 24) | 10 | 30 | 14 | 5.26 | 3.37* | ¶¶¶u | |
| Middle frontal gyrus (BA 8) | 20 | 32 | 38 | 5.39 | 3.41* | ¶¶¶u | |
| Superior frontal gyrus (BA 9) | 6,−10 | 50,56 | 28,18 | 4.96,4.06 | 3.26*,2.91 | ¶¶u | |
| C. Between group differences | |||||||
| Activations in DO group > no DO | |||||||
| SMA (Postcentral gyrus, BA 3) | 18 | −36 | 62 | 2.94 | 2.71 | ||
Regional statistic reported as Student’s t-value and Z-value. Coordinates are given in MNI space. All images reported attain significance at threshold P<0.01 uncorrected. Further voxelwise significance:
*
P<0.001 uncorrected;
**
P<0.0001 uncorrected. Cluster-level significance:
¶
P< 0.01;
¶¶
P<0.001;
¶¶¶
P<0.0001 (u = uncorrected, c = corrected at cluster level).