TABLE 2. Effect of Immunosuppression and Provocative Maneuvers.
FMR = fetal mouse retina, FVM = fetal ventral mesencephalon, MHC = major histocompatibility antigen, RPE = retinal pigment epithelial cells
| Origin of tissue |
Host | Immunosuppression | Provocative Maneuver |
Effect | Representative References |
|---|---|---|---|---|---|
| FMR | Adult Rat | Cyclosporine A | n/a | Healthy Graft |
[120, 132] |
| FMR | Adult Rat | None | n/a | Rejection | [120, 132] |
| FMR | Neonatal Rat |
None | Gamma- interferon |
Rejection | [117] |
| FMR | Neonatal Rat |
None | Blood-brain barrier disruption | Rejection | [133] |
| FMR | Neonatal Rat |
None | Removal of Host-Eye |
Rejection | [134] |
| FMR | Neonatal Rat |
None | Skin graft | Rejection | [134, 135] |
| FMR | Neonatal Rat |
Cyclosporine A | Removal of Host-Eye |
Healthy Graft |
[136] |
| FMR | Neonatal Rat |
Cyclosporine A | Removal of Cyclosporine |
Rejection | [137] |
| Rat FVM | Adult Rat or MHC deficient mice |
None | MHC class I deficient mice |
Variable; | [138, 139] |
| Rat FVM | Adult Guinea- Pigs |
None | n/a | Variable | [138] |
| Rat FVM | Adult Rat | None | Skin graft | Rejection | [140] |
| Rat FVM | Adult Rat | None | Spleen cell injection |
Host immune response/ rejection |
[22, 99, 141]. |
| Mouse FVM |
Adult Rat | None | n/a | Rejection | [138, 142, 143] |
| Mouse FVM |
Adult rat | Cyclosporine A or Methylprednisolone |
n/a | Healthy Graft |
[13, 143, 144] |
| MHC deficient mouse FVM |
Adult rat | None | n/a | Healthy Graft |
[142] |
| Mouse FVM |
Adult Guinea- Pigs |
None | Preformed anti-mouse antibodies |
Rejection | [138] |
| Monkey FVM |
Monkey | None | n/a | Healthy Graft |
[46, 145-152] [146] |
| Porcine FVM |
Adult Rat | Cyclosporine A | n/a | Healthy Graft |
[57] |
| Porcine FVM |
Adult Rat | Antigenic Masking | n/a | Healthy Graft |
[153] |
| Porcine FVM |
Human with PD |
Cyclosporine A | Pre-existing Antibodies |
Variable | [53, 56, 154] |
| Human FVM |
Human with PD |
Cyclosporine A | n/a | Variable | [43, 49, 93, 155] |
| Human FVM |
Adult Rat | Cyclosporine A, liposomal tacrolimus, microcarrier attachment, sertoli cells |
n/a | Healthy Graft or reduced host immune response |
[156-159] |
| Embryonic Human RPE |
Adult Rat | None | n/a | Healthy graft |
[62] |
| Embryonic Human RPE |
Monkey | None | n/a | Healthy graft |
[61] |
| Embryonic Human RPE |
Human with PD |
None | n/a | No pathology available |
[63, 64] |
| Post natal Human RPE |
Human with PD |
None | n/a | Poor graft survival in one hemibrain |
[68, 113] |