Table 3. Simple and multiple logistic regression (LR) performing an additive approach for assessing possible association between rs12188950 and ischaemic stroke risk for Lund Stroke Register (LSR), Malmö Diet and Cancer study (MDC) and the Sahlgrenska Academy Study on Ischemic Stroke (SAHLSIS).

		Simple LR		Weighted Simple LRa		Weighted Multiple LRa
Population	Covariate	OR; 95% CI; P-value	Number of non-missing cases/controls	OR; 95% CI; P-value	Number of non-missing cases/controls	Controlling for IS risk factorsb OR; 95% CI; P-value	Number of non-missing cases/controls
LSR	rs12188950	0.88; 0.72–1.08; 0.214	920/566	0.86; 0.70–1.06; 0.154	920/566	0.88; 0.70–1.10; 0.253	856/562
	Hypertension					1.73; 1.37–2.18; <0.001
	Diabetes					4.18; 2.94–5.96; <0.001
	Current smoker					2.61; 1.92–3.55; <0.001
MDC	rs12188950	0.99; 0.82–1.20; 0.920	874/881	0.93; 0.77–1.13; 0.478	874/818	0.98; 0.80–1.21; 0.873	849/795
	Hypertension					2.02; 1.63–2.50; <0.001
	Diabetes					4.73; 2.86–7.82; <0.001
	Current smoker					2.45; 1.95–3.07; <0.001
SAHLSIS	rs12188950	0.90; 0.72–1.13; 0.372	805/646	0.91; 0.73–1.14; 0.419	805/646	0.86; 0.67–1.09; 0.215	793/645
	Hypertension					2.52; 2.00–3.16; <0.001
	Diabetes					3.86; 2.64–5.66; <0.001
	Current smoker					3.37; 2.56–4.42; <0.001
Pooled data	rs12188950	0.93; 0.83–1.05; 0.240	2599/2093	0.90; 0.80–1.02; 0.095	2599/2030	0.91; 0.80–1.04; 0.159	2498/2002
	Hypertension					2.02; 1.77–2.29; <0.001
	Diabetes					4.40; 3.50–5.53; <0.001
	Current smoker					2.64; 2.28–3.07; <0.001

Abbreviations: CI, confidence interval; OR, odds ratio.

^aWeight obtained by age and sex standardization of included populations.

^bDichotomous risk factors for ischaemic stroke: hypertension, diabetes mellitus and current smoking.