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. 2012 Mar 30;26(6):872–881. doi: 10.1038/eye.2012.52

Figure 1.

Figure 1

Rag-1 KO mice develop all cardinal features of PVR. Representative PVR manifestations are shown for a total of 45 Rag-1 KO mice studied 2–8 weeks after injection of dispase. (a) Traction membrane in dispase-injected eye as indicated by arrow. (b) Proliferative membrane in vitreal cavity and retinal detachment as indicated by arrow. (c) Immunofluorescence staining for α-SMA (c-1), GFAP (c-2), GS (c-5), and RPE-65 (c-6) in the epiretinal membrane (EM), and Hoechst 33342 staining to mark cell nuclei with the EM (c-3 and c-7). c-4 is the merged picture of c-1–c-3, and c-8 is the merged picture of c-5–c-7 (triple staining).