Table 1. Interaction Effects of Familiarity and Treatment.
| Region | Right/left | Brodmann area | Cluster size (voxels) | Z-score | p-value (uncorr.) |
MNI-coordinates |
||
|---|---|---|---|---|---|---|---|---|
| |
|
|
|
|
|
x |
y |
z |
| Neural activation: familiarity × treatment | ||||||||
| Decrease by oxytocin: own child > familiar child (PL [oC>fC] > OT [oC>fC]) | ||||||||
| Globus pallidus* | L | 8 | 3.56 | <0.001 | −12 | 6 | 0 | |
| Increase by oxytocin: own child > unfamiliar child (OT [oC>uC] > PL [oC>uC]) | ||||||||
| Caudate body | L | 8 | 3.48 | <0.001 | −15 | 6 | 21 | |
| Decrease by oxytocin: unfamiliar child > familiar child (PL [uC>fC] > OT [uC>fC]) | ||||||||
| Globus pallidus* | L | 17 | 3.85 | <0.001 | −12 | 3 | 3 | |
| Precentral gyrus | L | 6 | 8 | 4.45 | <0.001 | −63 | 3 | 18 |
| Hippocampus* | L | 35 | 1 | 3.58 | <0.05 | −24 | −9 | −27 |
| Middle temporal gyrus | L | 22 | 7 | 3.60 | <0.001 | −45 | 3 | −21 |
| R | 21 | 10 | 3.97 | <0.001 | 63 | −9 | −24 | |
| Superior temporal gyrus | L | 21 | 10 | 3.59 | <0.001 | −45 | −18 | −12 |
| Supramarginal gyrus | L | 40 | 7 | 3.54 | <0.001 | −45 | −33 | 33 |
The whole-brain analysis was thresholded at an uncorrected p<0.001 with a cluster extent threshold of k=7 voxels. *Significant at p<0.05 corrected for multiple comparisons within the anatomical ROI. fC, familiar child; oC, own child; OT, oxytocin; PL, placebo; uC, unfamiliar child.