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. Author manuscript; available in PMC: 2012 Jun 17.
Published in final edited form as: Curr Biol. 2011 Apr 26;21(8):R280–R282. doi: 10.1016/j.cub.2011.03.035

Figure 1. RhoC regulates cofilin activity in invadopodia.

Figure 1

RhoC is activated by p190RhoGEF and these two proteins form a ring around the periphery of invadopodial cores, inactivating cofilin through the ROCK–LIMK pathway. RhoC is inactivated by p190RhoGAP within invadopodial cores, allowing active cofilin to generate actin barbed ends and promote polymerization.