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. Author manuscript; available in PMC: 2013 Jun 1.
Published in final edited form as: Bioorg Med Chem Lett. 2012 Apr 12;22(11):3791–3794. doi: 10.1016/j.bmcl.2012.04.003

Table 1.

Rate constants for 1, 5, and 6.

Compound Conditions kobs (min-1) t1/2
5 no thiol 5 (70 μM); MOPS (250 mM, pH 7); MeCN (25% v/v); 24 °C 13.2 ± 0.01 × 10−3 53 min
6 no thiol 6 (70 μM); MOPS (250 mM, pH 7); MeCN (25% v/v); 24 °C 6.2 ± 0.6 × 10−3 112 min
1 no thiol 1 (70 μM); MOPS (250 mM, pH 7); MeCN (25% v/v); 24 °C 0.408 ± 0.001 × 10−3 27 h
5 + thiol 5 (70 μM); GSH (700 μM) MOPS (300 mM, pH 7); MeCN (25% v/v); 24 °C 24.3 ± 0.1 × 10−2 2.8 min
6 + thiol 5 (70 μM); GSH (700 μM) MOPS (300 mM, pH 7); MeCN (25% v/v); 24 °C 18.3 ± 0.2 × 10−2 3.8 min
1 + thiol 5 (70 μM); GSH (700 μM) MOPS (300 mM, pH 7); MeCN (25% v/v); 24 °C 6.67 ± 0.01 × 10−2 10.4 min