Table 2.
Two-Point Linkage Analysis for Markers across Chromosome 5p
Markers | Position (cM) | Physical Position (Mb) |
LOD Score at Recombination Fraction, θ |
|||
---|---|---|---|---|---|---|
0.00 | 0.05 | 0.2 | 0.4 | |||
D5S1981 | 1.7200 | 1.155 | 0.4327 | 0.3972 | 0.2597 | 0.0585 |
D5S406 | 11.8500 | 4.994 | 2.7729 | 2.4887 | 1.6231 | 0.5141 |
D5S2505 | 14.3000 | 5.817 | 1.6695 | 1.4721 | 0.8628 | 0.1437 |
D5S580 | 17.8700 | 8.141 | 0.4327 | 0.3972 | 0.2597 | 0.0585 |
D5S630 | 19.6710 | 9.561 | 0.4327 | 0.3972 | 0.2597 | 0.0585 |
The EasyLINKAGE program26 was used. The physical positions are according to UCSC Feb 2009 (GRCh37/hg19) assembly. For reference, the common homozygosity-by-descent (HBD) locus for the Pakistani family and the Iranian family5 extends from SNPs rs1824938 (5.092 Mb) to rs2914296 (7.657 Mb), and NSUN2 is located between 6.599 and 6.633 Mb.