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. 2011 Nov 7;73(4):518–535. doi: 10.1111/j.1365-2125.2011.04139.x

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© 2011 The Author. British Journal of Clinical Pharmacology © 2011 The British Pharmacological Society

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Changes in carotid arterial stiffness in 30 patients with hypercholesterolaemia randomized to receive either pitavastatin (1–2 mg day⁻¹, n = 15) or diet and exercise therapy for 12 months. Carotid ultrasonography was used to reveal end-systolic and end-diastolic diameters of the common carotid artery, Ds and Dd, respectively, and arterial stiffness, β, was calculated using the formula ln(SBP/DBP)/[(Ds – Dd)/Dd], where SBP and DBP are the systolic and diastolic blood pressures, respectively. *P < 0.05 vs. no statin group after treatment. Data from Mizuguchi et al. [102]. Baseline (□); 12 months ()

Inline graphic — Changes in carotid arterial stiffness in 30 patients with hypercholesterolaemia randomized to receive either pitavastatin (1–2 mg day⁻¹, n = 15) or diet and exercise therapy for 12 months. Carotid ultrasonography was used to reveal end-systolic and end-diastolic diameters of the common carotid artery, Ds and Dd, respectively, and arterial stiffness, β, was calculated using the formula ln(SBP/DBP)/[(Ds – Dd)/Dd], where SBP and DBP are the systolic and diastolic blood pressures, respectively. *P < 0.05 vs. no statin group after treatment. Data from Mizuguchi et al. [102]. Baseline (□); 12 months ()