Table 4.
Bias (MPE), precision (MAPE) (%) of different combinations of blood sampling time points used with the population model to estimate the CsA AUC, compared with the AUC calculated according to the trapezoidal method
| Time points blood sampling (h) | Bias | (95% CI) (%) | Precision | (95% CI) (%) |
|---|---|---|---|---|
| 0 (with model) | 3.5 | (−1.9, 8.8) | 10.0 | (7.0, 13.1) |
| 2 | 4.4 | (−6.5, 15.4) | 20.2 | (14.2, 26.3) |
| 3 | 4.9 | (−0.8, 10.6) | 11.1 | (7.7, 14.5) |
| 5 | −4.7 | (−11.0, 1.7) | 11.7 | (7.7, 15.7) |
| 8 | 5.1 | (−0.8, 11.0) | 10.8 | (6.8, 14.8) |
| 0, 2 | 1.7 | (−2.3, 5.6) | 6.5 | (3.7, 9.2) |
| 0, 3 | 2.2 | (−2.0, 6.3) | 7.7 | (5.3, 10.0) |
| 0, 5 | −2.3 | (−7.8, 3.1) | 9.2 | (5.6, 12.7) |
| 0, 8 | −10.6 | (−16.5, −4.7) | 14.6 | (10.8, 18.3) |
| 0, 1, 2 | 1.3 | (−2.6, 5.2) | 6.0 | (3.2, 8.8) |
| 0, 1, 3 | −0.1 | (−3.7, 3.6) | 5.8 | (3.4, 8.3) |
| 0, 1.5, 3 | 1.6 | (−1.2, 4.5) | 4.6 | (2.6, 6.7) |
| 0, 2, 3 | 1.0 | (−1.4, 3.4) | 3.7 | (2.1, 5.3) |
| 0, 2, 5 | 4.1 | (1.4, 6.8) | 5.7 | (3.8, 7.7) |
| 0, 2, 8 | 1.7 | (−0.9, 4.3) | 4.4 | (2.6, 6.2) |
| 0, 3, 5 | 7.1 | (4.2, 10.0) | 8.0 | (5.7, 10.3) |
| 0; 3; 8 | 8.4 | (4.7, 12.0) | 9.1 | (5.9, 12.3) |
| 0, 1, 2, 3 | 4.6 | (2.3, 6.8) | 5.9 | (4.4, 7.4) |
| 0, 2, 3, 5 | 4.5 | (1.9, 7.1) | 5.9 | (4.1, 7.8) |
| 0, 2, 3, 8 | 2.8 | (0.4, 5.1) | 4.5 | (2.8, 6.2) |
| 0, 1, 2, 3, 5, 8, 12 | −0.7 | (−1.7, 0.3) | 1.9 | (1.2, 2.5) |